FADD Rabbit Monoclonal Antibody (CAB19049)
- SKU:
- CAB19049
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | FADD Rabbit Monoclonal Antibody |
SKU: | CAB19049 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human FADD (Q13158). |
Sequence: | LTEL KFLC LGRV GKRK LERV QSGL DLFS MLLE QNDL EPGH TELL RELL ASLR RHDL LRRV DDFE AGAA AGAA PGEE DLCA AFNV ICDN VGKD WRRL ARQL KVSD TKID SIED RYPR NLTE RVRE SLRI WKN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | GIG3; IMD90; MORT1; FADD |
Positive Sample: | HeLa,A431,U-251MG |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, neuron projection, nucleus, plasma membrane |
Calculated MW: | 23kDa |
Observed MW: | 25kDa |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Purification Method: | Affinity purification |
Gene ID: | 8772 |
Clone Number: | ARC0415 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |