FADD Rabbit Polyclonal Antibody (CAB16459)
- SKU:
- CAB16459
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | FADD Rabbit Polyclonal Antibody |
SKU: | CAB16459 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1). |
Sequence: | MDPF LVLL HSVS SSLS SSEL TELK FLCL GRVG KRKL ERVQ SGLD LFSM LLEQ NDLE PGHT ELLR ELLA SLRR HDLL RRVD DFEA GAAA GAAP GEED LCAA FNVI CDNV GKDW RRLA RQLK VSDT KIDS IEDR YPRN LTER VRES LRIW KNTE KENA TVAH LVGA LRSC QMNL VADL VQEV QQAR DLQN RSGA MSPM SWNS DAST SEAS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | GIG3; IMD90; MORT1; FADD |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, neuron projection, nucleus, plasma membrane, ripoptosome |
Calculated MW: | 23kDa |
Observed MW: | 28kDa |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Purification Method: | Affinity purification |
Gene ID: | 8772 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |