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FADD Monoclonal Antibody [PJ1D2AT] (CPAB0528)

SKU:
CPAB0528
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
PJ1D2AT
Applications:
WB
ELISA
IHC
€149
Frequently bought together:

Description

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FADD Monoclonal Antibody [PJ1D2AT] (CPAB0528)

The FADD Polyclonal Antibody (CPAB0528) is a valuable tool for researchers studying FADD, a key protein involved in apoptosis signaling pathways. Raised in rabbits, this antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to FADD, researchers can accurately detect and analyze the protein in various cell types, making it an excellent choice for studies in cell biology, cancer research, and drug development.FADD, also known as Fas-associated death domain protein, plays a crucial role in the regulation of cell death pathways, making it a promising target for therapies aimed at manipulating apoptosis in disease states.

Understanding the function and regulation of FADD is essential for advancing our knowledge of cell death mechanisms and developing novel treatments for conditions such as cancer, immune disorders, and neurodegenerative diseases. The FADD Polyclonal Antibody (CPAB0528) is a valuable tool for researchers seeking to unravel the complexities of apoptosis and its role in human health and disease.

Product Name:FADD Antibody
Product Sku:CPAB0528
Size:5μg
Host Species:Mouse
Immunogen:Anti-human FADD mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human FADD amino acids 1-28 purified from Ecoli.
Clone:PJ1D2AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Immunohistochemistry
Purification Method:FADD antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:FADD is an adaptor protein that cooperates with a variety of cell surface receptors and mediates cell apoptotic signals. Using its C-terminal death domain, FADD is recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and consequently it take parts in the death signaling initiated by these receptors. FADD interaction with the receptors reviels the N-terminal effector domain of, which allows it to recruit caspase-8, and thus initiate the cysteine protease cascade. Knockout studies in mice furthermore propose the significance of FADD in premature T cell development. FADD plays a role in survival/proliferation and cell cycle development. FADD also takes part in cellular sublocalization, protein phosphorylation, and inhibitory molecules.
Synonyms:GIG3, MORT1, MGC8528, FADD, Fas (TNFRSF6)-associated via death domain, Protein FADD, FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Growth-inhibiting gene 3 protein.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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