The FAAP20 Polyclonal Antibody (PAC046674) is a valuable tool for researchers studying FAAP20, a key protein involved in DNA damage response and repair mechanisms. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to FAAP20, the antibody enables the detection and analysis of this protein in various cell types, making it ideal for investigations in molecular biology and cancer research.FAAP20 is a crucial component of the FA core complex, which plays a vital role in the repair of interstand crosslinks in DNA and maintenance of genome stability. Dysregulation of FAAP20 has been linked to increased genomic instability and the development of cancer.
Therefore, research focused on understanding the function and regulation of FAAP20 is essential for the development of targeted therapies for cancer treatment.By utilizing the FAAP20 Polyclonal Antibody, researchers can gain valuable insights into the role of FAAP20 in DNA damage response pathways, leading to a better understanding of the mechanisms involved in cancer development and potential therapeutic interventions. This antibody offers a reliable tool for studies aiming to unravel the complexities of DNA repair mechanisms and their implications in disease.
Antibody Name:
FAAP20 Antibody (PACO46674)
Antibody SKU:
PACO46674
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Fanconi anemia core complex-associated protein 20 protein (14-179AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO46674 at dilution of 1:100.
Background:
Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
Synonyms:
Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa), FAAP20, C1orf86
