The FA2H Polyclonal Antibody (CAB13873) is a valuable tool for researchers studying the FA2H protein, a key player in lipid metabolism and neurological function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the FA2H protein, researchers can accurately detect and analyze FA2H expression in various cell types, making it ideal for investigations in neurology, lipid metabolism, and related fields.FA2H, also known as fatty acid 2-hydroxylase, is essential for the synthesis of myelin, the protective sheath surrounding nerve fibers. Mutations in the FA2H gene have been linked to a variety of neurological disorders, highlighting the importance of understanding FA2H function in both health and disease.
Research into FA2H may lead to insights into conditions such as leukodystrophy and multiple sclerosis, as well as potential therapeutic strategies targeting lipid metabolism in the nervous system.Overall, the FA2H Polyclonal Antibody is a valuable resource for scientists investigating the role of FA2H in neurological health and disease, offering a reliable tool for protein analysis and contributing to advancements in our understanding of lipid metabolism and neurologic disorders.
Product Name:
FA2H Rabbit Polyclonal Antibody
SKU:
CAB13873
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 95-170 of human FA2H (NP_077282.3).
This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia.
Purification Method:
Affinity purification
Gene ID:
79152
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FA2H Rabbit pAb (CAB13873) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
