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F9 Monoclonal Antibody [NYRhFIX] (CPAB0492)

SKU:
CPAB0492
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
NYRhFIX
Applications:
WB
ELISA
€660
Frequently bought together:

Description

system_update_alt Datasheet

F9 Monoclonal Antibody [NYRhFIX] (CPAB0492)

The F9 Polyclonal Antibody (CPAB0492) is a vital tool for researchers studying the F9 protein, a key factor in the coagulation cascade, specifically in the intrinsic pathway of blood clotting. This antibody, produced in rabbits, exhibits high specificity in detecting F9 in human samples and is validated for use in Western blot applications. By binding to the F9 protein, this antibody enables researchers to accurately assess F9 levels in various cell types, making it an essential tool for studies in hemostasis and thrombosis.F9, also known as factor IX, plays a crucial role in the blood clotting process by forming a complex with other proteins to activate the conversion of prothrombin to thrombin.

Understanding the function and regulation of F9 is essential for unraveling the mechanisms behind coagulation disorders such as hemophilia B and thrombophilia. By elucidating the role of F9 in these conditions, researchers can potentially develop more effective therapies for patients with these bleeding disorders.Overall, the F9 Polyclonal Antibody (CPAB0492) serves as a valuable resource for investigators delving into the intricacies of blood clotting and coagulation disorders, providing key insights into the role of F9 in health and disease.

Product Name:F9 Antibody
Product Sku:CPAB0492
Size:500μg
Host Species:Mouse
Immunogen:Human Factor-IX
Clone:NYRhFIX.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:Protein A
Isotype:IgG1
Background:Factor IX is a glycoprotein, which is synthesized in the liver. The domain structure of factor IX is similar to that of the other vitamin K dependent coagulation factors. The NH2-terminal region contains 12 g-carboxyglutamic acid (gla) residues, which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. Two domains which are homologous to epidermal growth factor (EGF) span the region between the NH2-terminal gla domain and the activation peptide (Ala-146 to Arg-180). Factor IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage at site A yields the intermediate IXa, which is subsequently converted to the fully active form IXab by cleavage at site B. The NH2-terminal light chain (GLA and EGF domains) remains covalently attached to the COOH-terminal heavy chain by a disulfide bond. The serine protease catalytic triad (Ser-365, His 221, Asp-269) is located in the heavy chain. Factor IXab is the catalytic component of the intrinsic factor Xase complex (factor VIIIa/IXa/Ca2+/phospholipid) which proteolytically activates factor X to factor Xa.
Synonyms:
Storage Buffer:In lyophilized form, for long periods, store at 4 C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 C.

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