F7 Rabbit Polyclonal Antibody (CAB16044)
- SKU:
- CAB16044
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | F7 Rabbit Polyclonal Antibody |
SKU: | CAB16044 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human F7 (NP_062562.1). |
Sequence: | RNLI AVLG EHDL SEHD GDEQ SRRV AQVI IPST YVPG TTNH DIAL LRLH QPVV LTDH VVPL CLPE RTFS ERTL AFVR FSLV SGWG QLLD RGAT ALEL MVLN VPRL MTQD CLQQ SRKV GDSP NITE YMFC AGYS DGSK DSCK GDSG GPHA THYR GTWY LTGI V |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | SPCA; F7 |
Positive Sample: | LO2,293T,Jurkat,Mouse lung,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted |
Calculated MW: | 52kDa |
Observed MW: | 46kDa |
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.
Purification Method: | Affinity purification |
Gene ID: | 2155 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |