Coagulation factor III/Tissue Factor Rabbit Polyclonal Antibody (CAB1378)
- SKU:
- CAB1378
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | Coagulation factor III/Tissue Factor Rabbit Polyclonal Antibody |
SKU: | CAB1378 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-251 of human Coagulation factor III/Tissue Factor (NP_001984.1). |
Sequence: | SAGE PLYE NSPE FTPY LETN LGQP TIQS FEQV GTKV NVTV EDER TLVR RNNT FLSL RDVF GKDL IYTL YYWK SSSS GKKT AKTN TNEF LIDV DKGE NYCF SVQA VIPS RTVN RKST DSPV ECMG QEKG EFRE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IF/ICC,1:50 - 1:200 |
Synonyms: | TF; TFA; CD142; Coagulation factor III/Tissue Factor |
Positive Sample: | BxPC-3,Mouse brain,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 53kDa/45kDa |
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 2152 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |