The F2RL3 Polyclonal Antibody (CAB8471) is a valuable tool for research involving F2RL3, a member of the G-protein coupled receptor family. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in a variety of applications, including Western blotting. By binding specifically to the F2RL3 protein, this antibody allows for detailed detection and analysis in diverse cell types, making it an essential component for studies in the fields of immunology and cancer research.
F2RL3, also known as PAR4, plays a crucial role in regulating cellular responses to thrombin stimulation, thereby influencing processes such as platelet activation and inflammation. Its involvement in these pathways makes F2RL3 a key target for investigations into conditions like cardiovascular disease, thrombosis, and inflammatory disorders. Unraveling the functions of F2RL3 is pivotal for the development of targeted therapies that could impact these disease states by modulating cellular responses to thrombin.
Product Name:
F2RL3 Rabbit Polyclonal Antibody
SKU:
CAB8471
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human F2RL3 (NP_003941.2).
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients.
Purification Method:
Affinity purification
Gene ID:
9002
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using F2RL3 antibody (CAB8471) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
