The F2R Polyclonal Antibody (CAB5641) is a vital tool for researchers studying the role of F2R, a cell surface receptor involved in coagulation and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications. By specifically binding to the F2R protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in hemostasis, thrombosis, and inflammatory processes. F2R, also known as the protease-activated receptor 1 (PAR-1), plays a crucial role in mediating cellular responses to thrombin, a key player in blood clotting and inflammation.
Dysregulation of F2R signaling has been implicated in various thrombotic disorders, cardiovascular diseases, and inflammatory conditions. With a deeper understanding of F2R function, researchers can uncover potential therapeutic targets for these diseases and develop new strategies for treatment. The F2R Polyclonal Antibody is a valuable tool for advancing our knowledge of F2R biology and its implications in health and disease.
Product Name:
F2R Rabbit Polyclonal Antibody
SKU:
CAB5641
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-110 of human F2R (NP_001983.2).
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2149
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using F2R antibody (CAB5641) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
