F2 Rabbit Polyclonal Antibody (CAB12382)
- SKU:
- CAB12382
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | F2 Rabbit Polyclonal Antibody |
SKU: | CAB12382 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 364-622 of human F2 (NP_000497.1). |
Sequence: | IVEG SDAE IGMS PWQV MLFR KSPQ ELLC GASL ISDR WVLT AAHC LLYP PWDK NFTE NDLL VRIG KHSR TRYE RNIE KISM LEKI YIHP RYNW RENL DRDI ALMK LKKP VAFS DYIH PVCL PDRE TAAS LLQA GYKG RVTG WGNL KETW TANV GKGQ PSVL QVVN LPIV ERPV CKDS TRIR ITDN MFCA GYKP DEGK RGDA CEGD SGGP FVMK SPFN NRWY QMGI VSWG EGCD RDGK YGFY THVF RLKK WIQK VIDQ FGE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | PT; THPH1; RPRGL2; F2 |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space. |
Calculated MW: | 70kDa |
Observed MW: | 75kDa |
This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure.
Purification Method: | Affinity purification |
Gene ID: | 2147 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |