The F11R Polyclonal Antibody (CAB1241) is specifically designed for research involving F11R, a cell adhesion molecule that plays a critical role in various physiological and pathological processes. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot and immunofluorescence applications. By binding to the F11R protein, this antibody allows for the detection and analysis of F11R in different cell types, making it an essential tool for studies in cell biology and disease research.F11R, also known as junctional adhesion molecule-A (JAM-A), is involved in cell adhesion and tight junction formation in epithelial and endothelial cells.
Its role in regulating cell-cell interactions makes it a key player in processes like inflammation, immune response, and tumor metastasis. Understanding the function and regulation of F11R is crucial for unraveling its implications in various diseases, such as cancer, cardiovascular disorders, and inflammatory conditions. The F11R Polyclonal Antibody provides researchers with a valuable tool to delve deeper into the mechanisms involving F11R and its potential as a therapeutic target.
Product Name:
F11R Rabbit Polyclonal Antibody
SKU:
CAB1241
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 28-238 of human JAM-A/CD321/F11R (NP_058642.1).
Cell junction, Cell membrane, Single-pass type I membrane protein, tight junction.
Calculated MW:
33kDa
Observed MW:
37kDa
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Purification Method:
Affinity purification
Gene ID:
50848
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using JAM-A/CD321/F11R Rabbit pAb (CAB1241) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
