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F10 Rabbit Polyclonal Antibody (CAB1452)

SKU:
CAB1452
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
  • Cardiovascular Antibodies Anti-F10 Antibody CAB1452
  • Cardiovascular Antibodies Anti-F10 Antibody CAB1452
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:F10 Rabbit Polyclonal Antibody
SKU:CAB1452
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 235-488 of human F10 (NP_000495.1).
Sequence:IVGG QECK DGEC PWQA LLIN EENE GFCG GTIL SEFY ILTA AHCL YQAK RFKV RVGD RNTE QEEG GEAV HEVE VVIK HNRF TKET YDFD IAVL RLKT PITF RMNV APAC LPER DWAE STLM TQKT GIVS GFGR THEK GRQS TRLK MLEV PYVD RNSC KLSS SFII TQNM FCAG YDTK QEDA CQGD SGGP HVTR FKDT YFVT GIVS WGEG CARK GKYG IYTK VTAF LKWI DRSM KTRG LPKA KSHA PEVI TSSP LK
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:10 - 1:100
Synonyms:FX; FXA; F10
Positive Sample:Raji,Mouse liver
Conjugate:Unconjugated
Cellular Localization:Secreted.
Calculated MW:55kDa
Observed MW:75kDa

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Purification Method:Affinity purification
Gene ID:2159
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using F10 antibody (CAB1452) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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