The Fibrinogen Antibody (PACO34650) is a polyclonal antibody specifically designed for research involving fibrinogen, a protein crucial for blood clotting. The antibody, produced in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and ELISA. By binding to fibrinogen, this antibody enables researchers to detect and analyze the protein in different biological samples, making it ideal for studies in hemostasis, thrombosis, and cardiovascular research.Fibrinogen is a key player in the blood coagulation process, essential for wound healing and preventing excessive bleeding. Dysregulation of fibrinogen levels or function can lead to various clotting disorders, cardiovascular diseases, and even thrombotic events.
Understanding the role of fibrinogen in these conditions is vital for developing effective diagnostic tools and therapeutic strategies to manage and treat these health issues.Overall, the Fibrinogen Antibody (PACO34650) serves as a valuable tool for researchers investigating the intricate mechanisms of fibrinogen function and its impact on various physiological and pathological processes in the human body. Its high specificity and sensitivity make it a reliable choice for advancing scientific discoveries in the field of coagulation biology and related disciplines.
Antibody Name:
F Antibody (PACO34650)
Antibody SKU:
PACO34650
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human respiRatory syncytial virus A
Immunogen:
Recombinant Human respiratory syncytial virus A Fusion glycoprotein F0 protein (27-529AA)
During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2. Interacts directly with heparan sulfate and may participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.
During virus entry, induces fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. The fusogenic activity is inactive untill entry into host cell endosome, where a furin-like protease cleaves off a small peptide between F1 and F2 (PubMed:18216092). Interacts directly with heparan sulfate and may participates in virus attachment (PubMed:10864656). Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity (PubMed:11493675). Later in infection, proteins F expressed at the plasma membrane of infected cells can mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis (PubMed:12663767).
