The Ezrin Polyclonal Antibody (CAB0703) is a valuable tool for researchers studying Ezrin, a protein that plays a key role in cell movement and organization. This antibody, produced in rabbits, has a high affinity for Ezrin in human samples and is suitable for use in Western blot applications. By binding specifically to Ezrin, this antibody allows for the detection and analysis of Ezrin expression in various cell types, making it ideal for investigations in cell biology and cancer research.Ezrin is a member of the ERM (ezrin, radixin, moesin) protein family that links the plasma membrane to the actin cytoskeleton, playing a crucial role in cell adhesion, migration, and signaling.
Dysregulation of Ezrin has been implicated in various diseases, including cancer, where it contributes to tumor invasion and metastasis. By studying the function and regulation of Ezrin, researchers can gain insights into the mechanisms underlying these pathological processes and identify potential therapeutic targets for intervention.
Product Name:
Ezrin Rabbit Polyclonal Antibody
SKU:
CAB0703
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-470 of human Ezrinin (NP_003370.2).
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
Purification Method:
Affinity purification
Gene ID:
7430
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ezrin Rabbit pAb (CAB0703) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
