The EZH2 Polyclonal Antibody (CAB5743) is a valuable tool for researchers studying EZH2, a protein associated with gene regulation and implicated in various diseases, including cancer. This rabbit polyclonal antibody is highly specific to human EZH2 and has been validated for use in Western blot and immunohistochemistry applications.EZH2 is a histone methyltransferase that plays a critical role in epigenetic regulation, particularly in controlling gene expression through histone methylation. Dysregulation of EZH2 has been linked to oncogenesis and tumor progression in multiple cancer types, making it an attractive target for cancer therapy research.
The EZH2 Polyclonal Antibody allows for the detection and analysis of EZH2 protein levels in different cell types and tissue samples, facilitating research in cancer biology and epigenetics. By understanding the role of EZH2 in gene regulation and disease development, researchers can potentially develop novel therapeutic strategies targeting EZH2 for the treatment of cancer and other diseases.
Product Name:
EZH2/KMT6 Rabbit Polyclonal Antibody
SKU:
CAB5743
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 133-252 of human EZH2/KMT6 (NP_001190176.1).
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
2146
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using EZH2/KMT6 Rabbit pAb (CAB5743) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
