The EZH2 Polyclonal Antibody (CAB16846) is a valuable tool for researchers studying EZH2, a histone methyltransferase involved in epigenetic regulation and cancer development. This antibody, raised in rabbits, is highly specific to EZH2 and is validated for use in immunohistochemistry and Western blot applications. It binds to the EZH2 protein, allowing for detection and analysis in various tissue samples, making it ideal for studies in oncology and epigenetics.EZH2 is a key player in controlling gene expression through histone methylation, making it a potential target for cancer therapy.
Dysregulation of EZH2 has been implicated in various types of cancer, including prostate, breast, and lymphoma. By understanding the role of EZH2 in tumorigenesis, researchers can develop new therapies targeting this enzyme and potentially improve cancer treatment outcomes.Overall, the EZH2 Polyclonal Antibody is a valuable tool for researchers investigating the complex role of EZH2 in cancer development and epigenetic regulation. Its high specificity and versatility make it a reliable choice for studying EZH2 expression and function in various biological contexts.
Product Name:
EZH2/KMT6 Rabbit Polyclonal Antibody
SKU:
CAB16846
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 158-261 of EZH2/KMT6 (NP_001190176.1).
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
2146
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using EZH2/KMT6 Rabbit pAb (CAB16846) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
