The EZH2 Polyclonal Antibody (CAB13867) is a valuable tool for researchers studying EZH2, a key epigenetic regulator involved in gene expression and cell differentiation. This antibody, raised in rabbits, is highly specific for EZH2 and has been validated for use in Western blot and immunohistochemistry applications. EZH2 is a histone methyltransferase that plays a critical role in maintaining gene silencing and is often overexpressed in various cancers, making it a potential therapeutic target. By binding to EZH2, this antibody enables accurate detection and analysis of EZH2 levels in various biological samples, providing valuable insights into its function in normal and disease states.
Research focused on EZH2 is essential for understanding its role in cancer development, stem cell regulation, and other biological processes. The EZH2 Polyclonal Antibody is a reliable tool for researchers seeking to explore the mechanisms underlying EZH2-mediated gene regulation and its implications in disease pathology.
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
2146
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HT-29 cells, using EZH2/KMT6 Rabbit pAb (CAB13867) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
