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EZH2/KMT6 Polyclonal Antibody

SKU:
CAB21997
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
Frequently bought together:

Description

EZH2/KMT6 Polyclonal Antibody (CAB21997)

The EZH2 (KMT6) Polyclonal Antibody is a valuable tool for researchers studying the EZH2 protein, a key player in epigenetic regulation and cancer development. This antibody, raised in rabbits, is highly specific to human EZH2 and has been validated for use in Western blot applications.EZH2, part of the Polycomb group proteins, plays a critical role in gene expression regulation by catalyzing the methylation of histone H3 at lysine 27. Dysregulation of EZH2 has been implicated in various cancers, making it a promising target for therapeutic interventions.

The EZH2 Polyclonal Antibody allows for the detection and analysis of EZH2 expression in different cell types, providing valuable insights into its functions in cancer biology and epigenetic control.With its high reactivity and specificity, the EZH2 Polyclonal Antibody is an essential tool for researchers investigating the mechanisms behind cancer development and potential therapeutic strategies targeting EZH2. Discover the potential of EZH2 in epigenetic research with this reliable antibody.

Product Name:EZH2/KMT6 Polyclonal Antibody
Product Code:CAB21997
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:MCF7, Neuro-2a
Cellular Location:cytoplasm, nucleoplasm, nucleus, pronucleus

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 158-261 of EZH2/KMT6 (NP_001190176.1).
Sequence:HGDRE CGFIN DEIFV ELVNA LGQYN DDDDD DDGDD PEERE EKQKD LEDHR DDKES RPPRK FPSDK IFEAI SSMFP DKGTA EELKE KYKEL TEQQL PGALP PECT
Synonyms:WVS, ENX1, KMT6, WVS2, ENX-1, EZH2b, KMT6A
Calculated MW:85kDa
Observed MW:98kDa

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