The EZH1 Polyclonal Antibody (CAB5818) is a powerful tool for researchers studying EZH1, a key protein involved in epigenetic regulation and gene expression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to EZH1, this antibody enables accurate detection and analysis of the protein in a variety of cell types, making it an invaluable asset for studies in epigenetics, cancer research, and developmental biology.EZH1 is a member of the Polycomb group proteins, which play a crucial role in controlling gene expression and maintaining cellular identity.
As a histone methyltransferase, EZH1 is involved in modifying chromatin structure and regulating transcriptional processes. Dysregulation of EZH1 has been linked to various diseases, including cancer and developmental disorders, making it a promising target for therapeutic interventions.Understanding the functions and mechanisms of EZH1 is essential for unraveling its role in health and disease. The EZH1 Polyclonal Antibody (CAB5818) provides researchers with a reliable tool to study EZH1 protein expression and activity, paving the way for advancements in epigenetics research and potential therapeutic strategies targeting EZH1-related pathways.
Product Name:
EZH1 Rabbit Polyclonal Antibody
SKU:
CAB5818
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 160-280 of human EZH1 (NP_001982.2).
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).
Purification Method:
Affinity purification
Gene ID:
2145
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse lung, using EZH1 antibody (CAB5818) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
