The EXTL1 Polyclonal Antibody (PACO19637) is a valuable tool for researchers studying EXTL1, a key enzyme involved in the biosynthesis of heparan sulfate, a crucial component of the extracellular matrix. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the EXTL1 protein, allowing for accurate detection and analysis in various cell types.EXTL1 plays a vital role in the regulation of cell growth, differentiation, and tissue development, making it an attractive target for studies in developmental biology, cancer research, and tissue regeneration.
By understanding the function of EXTL1, researchers can gain valuable insights into disease mechanisms and potentially uncover new therapeutic targets for a range of conditions.In summary, the EXTL1 Polyclonal Antibody offers reliable and specific detection of EXTL1 protein, making it an essential tool for researchers looking to explore the biological functions and potential therapeutic applications of this enzyme.
Antibody Name:
EXTL1 Antibody (PACO19637)
Antibody SKU:
PACO19637
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human EXTL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO19637(EXTL1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19637(EXTL1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors α 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.
Synonyms:
exostosin-like glycosyltransferase 1
UniProt Protein Function:
EXTL1: Probable glycosyltransferase. Belongs to the glycosyltransferase 47 family.Protein type: Membrane protein, integral; Transferase; Glycan Metabolism - heparan sulfate biosynthesis; EC 2.4.1.224Chromosomal Location of Human Ortholog: 1p36.1Biological Process: skeletal development
UniProt Protein Details:
NCBI Summary:
This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008]
