The Exostosin-2 Polyclonal Antibody (CAB1973) is a valuable tool for researchers studying Exostosin-2, a key enzyme involved in the biosynthesis of heparan sulfate proteoglycans. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the Exostosin-2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies focusing on glycosaminoglycan biosynthesis and related pathways.Exostosin-2, also known as EXT2, plays a crucial role in heparan sulfate synthesis, which is essential for various biological processes such as cell signaling, development, and tissue organization.
Dysregulation of Exostosin-2 activity has been linked to developmental disorders and cancer, highlighting the importance of understanding its function and regulation. By investigating the role of Exostosin-2 in different cellular contexts, researchers can gain insights into disease mechanisms and potential therapeutic targets related to glycosaminoglycan metabolism.
Product Name:
EXT2 Rabbit Polyclonal Antibody
SKU:
CAB1973
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-340 of human EXT2 (NP_000392.3).
Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
82kDa
Observed MW:
82kDa
This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
2132
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EXT2 antibody (CAB1973) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
