The EXPH5 Antibody (PAC046918) is a polyclonal antibody designed for research involving the EXPH5 protein. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding to the EXPH5 protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it an essential tool for studies in cell biology and molecular biology.EXPH5 is a protein involved in cellular transport processes, particularly in intracellular vesicle trafficking and membrane fusion events. Its role in regulating vesicle transport and membrane dynamics makes it a key player in cellular function and signaling pathways.
Research on EXPH5 is crucial for understanding fundamental cellular processes and their implications in various physiological and pathological conditions.By utilizing the EXPH5 Antibody (PAC046918), researchers can investigate the function and localization of the EXPH5 protein in different cellular contexts, providing insights into its mechanisms of action and potential therapeutic targets. This antibody is a valuable resource for studies in cell biology, biochemistry, and pharmacology, offering a deeper understanding of the intricate mechanisms governing cellular processes.
Antibody Name:
EXPH5 Antibody (PACO46918)
Antibody SKU:
PACO46918
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Exophilin-5 protein (1235-1490AA)
Immunohistochemistry of paraffin-embedded human lung tissue using PACO46918 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human melanoma using PACO46918 at dilution of 1:100.
Background:
May act as Rab effector protein and play a role in vesicle trafficking.
Synonyms:
Exophilin-5 (Synaptotagmin-like protein homolog lacking C2 domains b) (SlaC2-b) (Slp homolog lacking C2 domains b), EXPH5, KIAA0624 SLAC2B
UniProt Protein Function:
exophilin 5: May act as Rab effector protein and play a role in vesicle trafficking. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, RabChromosomal Location of Human Ortholog: 11q22.3Cellular Component: endosomeMolecular Function: Rab GTPase bindingBiological Process: intracellular protein transport; positive regulation of protein secretion; positive regulation of exocytosisDisease: Epidermolysis Bullosa, Nonspecific, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the synaptotagmin-like protein (Slp) family lacking a C2 domain. It contains an N-terminal synaptotagmin-like homology domain (SHD), and is a ras-related protein Rab-27B effector protein. This protein is thought to be involved in exosome secretion and intracellular vesicle trafficking. Reduced expression of this gene results in keratin filament defects. Mutations in this gene have been associated with some cases of epidermolysis bullosa, an inherited skin fragility disorder. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
