The Exostosin-1 Polyclonal Antibody (CAB2030) is a valuable tool for researchers studying the Exostosin-1 protein, a key player in heparan sulfate biosynthesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to Exostosin-1, this antibody allows for the detection and analysis of the protein in various cell types, making it an essential component for studies in glycobiology and cancer research.Exostosin-1 is involved in the process of heparan sulfate proteoglycan biosynthesis, playing a crucial role in cell growth, differentiation, and signaling.
Dysregulation of Exostosin-1 has been implicated in various diseases, including cancer and developmental disorders. By understanding the function of Exostosin-1, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention. Unlock the potential of Exostosin-1 research with the CAB2030 Polyclonal Antibody from Assaygenie.
Product Name:
EXT1 Rabbit Polyclonal Antibody
SKU:
CAB2030
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 467-746 of human EXT1 (NP_000118.2).
Endoplasmic reticulum membrane, Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
86kDa
Observed MW:
86kDa
This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses.
Purification Method:
Affinity purification
Gene ID:
2131
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EXT1 antibody (CAB2030) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
