The EXOSC3 Polyclonal Antibody (CAB11623) is an essential tool for researchers studying EXOSC3, a key component of the exosome complex responsible for RNA processing and degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the EXOSC3 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in RNA biology and gene expression regulation.
EXOSC3 is known to play a crucial role in maintaining RNA integrity and stability, making it a target of interest in studies related to RNA metabolism, RNA surveillance, and RNA degradation pathways. Dysregulation of EXOSC3 has been linked to various human diseases, including neurodegenerative disorders and cancer. Understanding the function and regulation of EXOSC3 is vital for advancing our knowledge of RNA processing mechanisms and developing potential therapeutic interventions for related diseases.
Product Name:
EXOSC3 Rabbit Polyclonal Antibody
SKU:
CAB11623
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human EXOSC3 (NP_057126.2).
This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
51010
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using EXOSC3 Rabbit pAb (CAB11623) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
