The ExoSC1 Polyclonal Antibody (CAB10302) is an essential tool for research involving ExoSC1, a key protein involved in exosome secretion and cell-to-cell communication. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.ExoSC1 is known to play a crucial role in mediating the biogenesis and release of exosomes, small extracellular vesicles that transport various biomolecules and signaling molecules between cells. By targeting ExoSC1 with this antibody, researchers can effectively detect and analyze the protein in different cell types, making it an ideal choice for studies in exosome biology and intercellular communication.
Understanding the function and regulation of ExoSC1 is essential for uncovering its role in physiological processes and diseases such as cancer, neurodegenerative disorders, and immune-related conditions. By utilizing the ExoSC1 Polyclonal Antibody, investigators can further explore the mechanisms underlying exosome formation and secretion, paving the way for the development of potential diagnostic and therapeutic strategies in the future.
Product Name:
EXOSC1 Rabbit Polyclonal Antibody
SKU:
CAB10302
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human EXOSC1 (NP_057130.1).
This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51013
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EXOSC1 antibody (CAB10302) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
