EXOC2 Polyclonal Antibody (CAB21568)
- SKU:
- CAB21568
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IF
- IP
Description
Product Name: | EXOC2 Polyclonal Antibody |
SKU: | CAB21568 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human EXOC2 (NP_060773.3). |
Sequence: | MSRS RQPP LVTG ISPN EGIP WTKV TIRG ENLG TGPT DLIG LTIC GHNC LLTA EWMS ASKI VCRV GQAK NDKG DIIV TTKS GGRG TSTV SFKL LKPE KIGI LDQS AVWV DEMN YYDM RTDR NKGI PPLS LRPA NPLG IEIE KSKF SQKD LEML FHGM SADF TSEN FSAA WYLI ENHS NTSF EQLK MAVT NLKR QANK KSEG SLAY VKGG LSTF FEAQ DALS |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | SEC5; Sec5p; SEC5L1; NEDFACH; EXOC2 |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, exocyst, plasma membrane |
Calculated MW: | 104kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 55770 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |