The Exoc2 Polyclonal Antibody is a valuable tool for research involving Exoc2, a protein involved in regulating exocytosis and vesicle trafficking. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the Exoc2 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in cell biology and neurobiology.Exoc2 is known to play a crucial role in mediating the release of neurotransmitters and hormones from cells, making it a key player in synaptic transmission and cell signaling.
Research on Exoc2 can provide insights into the mechanisms underlying neuronal communication and may have implications for understanding neurological disorders and synaptic dysfunction. The Exoc2 Polyclonal Antibody is a valuable tool for researchers looking to investigate the functions of Exoc2 and its role in cellular processes.
Product Name:
EXOC2 Polyclonal Antibody
SKU:
CAB21568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human EXOC2 (NP_060773.3).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
SEC5; Sec5p; SEC5L1; NEDFACH; EXOC2
Conjugate:
Unconjugated
Cellular Localization:
cytosol, exocyst, plasma membrane
Calculated MW:
104kDa
Observed MW:
Refer to figures
The protein encoded by this gene is a component of the exocyst complex, a multi-protein complex essential for the polarized targeting of exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. This protein has been shown to interact with the Ral subfamily of GTPases and thereby mediate exocytosis by tethering vesicles to the plasma membrane. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55770
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using EXOC2 Rabbit pAb (CAB21568) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
