The Exendin-4 Antibody (PAC019630) is a polyclonal antibody specifically designed for research involving Exendin-4, a peptide with therapeutic potential for diabetes treatment. The antibody, produced using high-quality materials, is highly reactive with human samples and has been validated for use in various applications including Western blotting. It binds specifically to Exendin-4 protein, allowing for accurate detection and analysis in different experimental settings.Exendin-4, a glucagon-like peptide 1 (GLP-1) receptor agonist, has attracted significant attention in the pharmaceutical industry for its ability to regulate blood sugar levels and improve insulin sensitivity. Its potential application in the treatment of diabetes makes it a valuable target for further research and development.
Understanding the mechanisms of action of Exendin-4 is crucial for advancing therapeutic strategies for diabetes management and related metabolic disorders. The Exendin-4 Antibody is an essential tool for researchers studying the effects of Exendin-4 on glucose metabolism, pancreatic function, and insulin signaling pathways. Its high specificity and reliability make it suitable for a wide range of experiments in molecular biology, pharmacology, and biomedical research. By utilizing this antibody, scientists can gain valuable insights into the therapeutic potential of Exendin-4 and contribute to the development of innovative treatments for diabetes.
Antibody Name:
Exendin-4 Antibody (PACO19630)
Antibody SKU:
PACO19630
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
ELISA:1:1000-1:2000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of Heloderma suspectum Exendin 4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Background:
Exendin 4 is a 39 amino acid, peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion. It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
Synonyms:
Exendin 4
UniProt Protein Function:
Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
