The EXD2 Antibody (PAC047082) is a high-quality polyclonal antibody designed for research involving the EXD2 protein, a critical player in DNA repair mechanisms. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunofluorescence applications.EXD2 is a key protein involved in maintaining genome stability and repairing DNA damage, making it an essential component in understanding cellular responses to exogenous and endogenous genotoxic stress. By targeting EXD2, researchers can gain valuable insights into the mechanisms underlying DNA repair processes and identify potential therapeutic targets for diseases related to genomic instability, such as cancer.
The EXD2 Antibody is a valuable tool for studying DNA repair pathways, genome maintenance, and cellular responses to DNA damage. Its specificity and sensitivity make it ideal for use in various research settings, including molecular biology, cancer biology, and genomics. Researchers can rely on this antibody to accurately detect and analyze EXD2 protein expression in different cell types, providing crucial information for advancing our understanding of DNA repair mechanisms and developing new strategies for treating diseases associated with genome instability.
Western Blot. Positive WB detected in: Mouse brain tissue, Mouse stomach tissue. All lanes: EXD2 antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 71, 57 kDa. Observed band size: 71 kDa..
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO47082 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO47082 at dilution of 1:100.
Background:
Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.
Synonyms:
Exonuclease 3'-5' domain-containing protein 2 (EC 3.1.11.1) (Exonuclease 3'-5' domain-like-containing protein 2), EXD2, C14orf114 EXDL2
UniProt Protein Function:
EXDL2: Belongs to the EXD2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 14q24.1Cellular Component: cytoplasm; nucleusMolecular Function: nucleic acid binding; 3'-5' exonuclease activity
