The EWSR1 Polyclonal Antibody (CAB13978) is a valuable tool for researchers studying the EWSR1 protein, a key player in various cellular processes such as RNA processing and gene regulation. This antibody, raised in rabbits, is highly specific for detecting EWSR1 in human samples and has been validated for use in Western blot applications. By binding to the EWSR1 protein, researchers can easily detect and analyze its expression in different cell types, making it ideal for studies in molecular biology and cancer research.EWSR1, also known as Ewing sarcoma breakpoint region 1, is a fusion protein commonly associated with Ewing sarcoma, a type of bone cancer that primarily affects children and young adults.
Understanding the functions and regulations of EWSR1 is crucial for developing targeted therapies and diagnostic tools for Ewing sarcoma patients. Additionally, EWSR1 has been implicated in other diseases and disorders, making it a promising target for further research in the fields of oncology and genetics.Overall, the EWSR1 Polyclonal Antibody is a reliable and specific tool for studying the functions and roles of the EWSR1 protein in various biological processes and disease contexts. Its high reactivity and specificity make it an essential component for researchers looking to further explore the implications of EWSR1 in health and disease.
Product Name:
EWSR1 Rabbit Polyclonal Antibody
SKU:
CAB13978
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EWSR1 (NP_001156757.1).
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Purification Method:
Affinity purification
Gene ID:
2130
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using EWSR1 antibody (CAB13978).
