EWSR1 Rabbit Polyclonal Antibody (CAB13978)
- SKU:
- CAB13978
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | EWSR1 Rabbit Polyclonal Antibody |
SKU: | CAB13978 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human EWSR1 (NP_001156757.1). |
Sequence: | MAST DYST YSQA AAQQ GYSA YTAQ PTQG YAQT TQAY GQQS YGTY GQPT DVSY TQAQ TTAT YGQT AYAT SYGQ PPTG YTTP TAPQ AYSQ PVQG YGTG AYDT TTAT VTTT QASY AAQS AYGT QPAY PAYG QQPA ATAP TRPQ DGNK PTET SQPQ SSTG GYNQ PSLG YGQS NYSY PQVP GSYP MQPV TAPP SYPP TSYS STQP TSYD QSSY SQQN TYGQ PSSY GQQS SYGQ QSSY GQQP PTSY PPQT GSYS QAPS QYSQ QSSS YGQQ SSFR QDHP SSMG VYGQ ESGG FSGP GENR SMSG PDNR |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:100 |
Synonyms: | EWS; EWS-FLI1; bK984G1.4; EWSR1 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Nucleus. |
Calculated MW: | 68kDa |
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
Purification Method: | Affinity purification |
Gene ID: | 2130 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |