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ETV6 Transcription Factor Activity Assay

SKU:
TFAB00100
Product Type:
ELISA Kit
ELISA Type:
Transcription Factor Assay
Analytes:
ETV6
Reactivity:
Human
Mouse
Rat
€599
Frequently bought together:

Description

system_update_altDatasheet
Product Name:ETV6 Transcription Factor Activity Assay
Product Code:TFAB00100
Target:ETV6
Synonyms:ETS translocation variant 6, ETS-related protein Tel1, Tel
Reactivity:Human, Mouse, Rat
Sample Types:Nuclear or cell lysates

The Assay Genie ETV6 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:4.5 hours
Detection Method:Colorimetric 450 nm
Size:12 x 8-Well Microstrips
Storage:4°C for 6 months
UniProt Protein Function:Tel: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML). Chromosomal aberrations involving ETV6 are found in a form of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with MN1; translocation t(4;12)(q12;p13) with CHIC2. Chromosomal aberrations involving ETV6 are found in childhood acute lymphoblastic leukemia (ALL). Translocations t(12;21)(p12;q22) and t(12;21)(p13;q22) with RUNX1/AML1. A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation t(9;12)(p24;p13) with JAK2. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS) with basophilia. Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ACSL6. A chromosomal aberration involving ETV6 is found in myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2. Defects in ETV6 are a cause of myeloproliferative disorder chronic with eosinophilia (MPE). A hematologic disorder characterized by malignant eosinophils proliferation. A chromosomal aberration involving ETV6 is found in many instances of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein. Defects in ETV6 are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. A chromosomal aberration involving ETV6 is found in acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5. Belongs to the ETS family.
UniProt Protein Details:

Protein type:Transcription factor; Oncoprotein; Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; nucleolus; nucleus

Molecular Function:protein binding; protein domain specific binding; transcription factor activity

Biological Process: cell differentiation; negative regulation of transcription from RNA polymerase II promoter

Disease: Thrombocytopenia 5

NCBI Summary:This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008]
UniProt Code:P41212
NCBI GenInfo Identifier:730927
NCBI Gene ID:2120
NCBI Accession:P41212.1
UniProt Secondary Accession:P41212,Q9UMF6, Q9UMF7, Q9UMG0, A3QVP6, A8K076,
UniProt Related Accession:P41212
Molecular Weight:53,000 Da
NCBI Full Name:Transcription factor ETV6
NCBI Synonym Full Names:ETS variant 6
NCBI Official Symbol:ETV6  
NCBI Official Synonym Symbols:TEL; THC5; TEL/ABL  
NCBI Protein Information:transcription factor ETV6
UniProt Protein Name:Transcription factor ETV6
UniProt Synonym Protein Names:ETS translocation variant 6; ETS-related protein Tel1; Tel
Protein Family:Transcription factor
UniProt Gene Name:ETV6  
UniProt Entry Name:ETV6_HUMAN
AntibodiesELISA Kits
Anti-ETV6 Antibody (CAB15668)Human ETV6 (ETS translocation variant 6) ELISA Kit (HUFI07935)
Anti-ETV6 Antibody (CAB1637)
ETV6 Antibody (PACO01604)
ETV6 Antibody (PACO02678)
ETV6 Antibody (PACO09158)

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