The ETV6 Polyclonal Antibody (CAB1637) is a valuable tool for researchers studying the ETV6 gene, a transcription factor involved in various cellular processes, including hematopoiesis and leukemogenesis. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.ETV6, also known as TEL (Translocation Ets Leukemia), plays a crucial role in normal cell development and differentiation. Mutations or alterations in the ETV6 gene have been linked to various cancers, including leukemia and solid tumors.
By targeting the ETV6 protein, researchers can better understand its function and involvement in disease progression.This antibody is suitable for immunology and cancer research, allowing for the detection and analysis of ETV6 protein expression in different cell types. By investigating the role of ETV6 in disease pathogenesis, researchers can potentially identify new therapeutic targets and strategies for treating ETV6-related conditions.
Product Name:
ETV6 Rabbit Polyclonal Antibody
SKU:
CAB1637
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1).
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
Purification Method:
Affinity purification
Gene ID:
2120
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ETV6 antibody (CAB1637) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
