The ETV6 Polyclonal Antibody (CAB15668) is a valuable tool for researchers studying the ETV6 protein, also known as ETS Translocation Variant 6. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ETV6 protein, this antibody enables the detection and analysis of ETV6 in various cell types, making it ideal for investigations in oncology and hematological disorders.ETV6 is a transcription factor with important roles in hematopoiesis and development.
It is implicated in a variety of cancers, including leukemia, breast cancer, and prostate cancer, making it a promising target for therapeutic interventions. Understanding the function and regulation of ETV6 is crucial for advancing our knowledge of cancer biology and identifying potential treatment strategies. The ETV6 Polyclonal Antibody offers researchers a reliable tool for exploring the roles of ETV6 in disease pathogenesis and progression.
Product Name:
ETV6 Rabbit Polyclonal Antibody
SKU:
CAB15668
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_001978.1).
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
Purification Method:
Affinity purification
Gene ID:
2120
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ETV6 Rabbit pAb (CAB15668) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
