The ETV1 Polyclonal Antibody (CAB13303) is a powerful tool for research involving the ETV1 protein, a transcription factor that plays a critical role in various cellular processes, including cell growth, differentiation, and survival. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.ETV1 is known for its involvement in several cancer types, including prostate cancer and melanoma, making it a valuable target for studies in oncology. By binding to the ETV1 protein, this antibody enables accurate detection and analysis in a variety of cell types, facilitating research into the mechanisms underlying tumorigenesis and potential therapeutic interventions.
Furthermore, ETV1 has been implicated in other physiological processes, such as neuronal development and tissue repair, suggesting its relevance in a broader range of fields beyond cancer research. By studying the function of ETV1 using this polyclonal antibody, researchers can gain valuable insights into its role in normal and pathological conditions, paving the way for novel discoveries and advancements in biomedical science.
Product Name:
ETV1 Rabbit Polyclonal Antibody
SKU:
CAB13303
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 80-300 of human ETV1 (NP_004947.2).
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
2115
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat pancreas using ETV1 Rabbit pAb (CAB13303) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
