Anti-ETS2 Antibody (CAB16844)
- SKU:
- CAB16844
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Anti-ETS2 Antibody (CAB16844)
The ETS2 Polyclonal Antibody (CAB16844) is a valuable tool for research involving the ETS2 transcription factor, a key regulator of gene expression in various cellular processes. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the ETS2 protein, allowing for detection and analysis in different cell types, making it ideal for studies in molecular biology and cancer research.
ETS2 is known for its role in controlling gene expression, cell proliferation, differentiation, and apoptosis. It is involved in numerous signaling pathways and has been implicated in various diseases, including cancer, developmental disorders, and neurological conditions. Understanding the function of ETS2 is crucial for unraveling its complex biological roles and developing targeted therapies for diseases associated with its dysregulation.
| Antibody Name: | Anti-ETS2 Antibody |
| Antibody SKU: | CAB16844 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human ETS2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide of human ETS2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2114 |
| Uniprot: | P15036 |
| Cellular Location: | |
| Calculated MW: | 53kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ETS2, ETS2IT1 |
| Background: | This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Ets-2: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus E26 oncogene. A target of the Akt/JNK signaling pathway in macrophages. A PKC pathway activates ETS2, up-regulating GM-CSF in non-small lung carcinoma cells. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 21q22.2 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; DNA binding; transcription factor activity; glucocorticoid receptor binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; skeletal development |
| NCBI Summary: | This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P15036 |
| NCBI GenInfo Identifier: | 119645 |
| NCBI Gene ID: | 2114 |
| NCBI Accession: | P15036.1 |
| UniProt Secondary Accession: | P15036,A1A4L6, |
| UniProt Related Accession: | P15036 |
| Molecular Weight: | 469 |
| NCBI Full Name: | Protein C-ets-2 |
| NCBI Synonym Full Names: | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
| NCBI Official Symbol: | ETS2Â Â |
| NCBI Official Synonym Symbols: | ETS2IT1Â Â |
| NCBI Protein Information: | protein C-ets-2; oncogene ETS-2; v-ets erythroblastosis virus E26 oncogene homolog 2; v-ets avian erythroblastosis virus E2 oncogene homolog 2 |
| UniProt Protein Name: | Protein C-ets-2 |
| Protein Family: | Protein |
| UniProt Gene Name: | ETS2Â Â |
| UniProt Entry Name: | ETS2_HUMAN |
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