Anti-ETS2 Antibody (CAB14486)
- SKU:
- CAB14486
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Anti-ETS2 Antibody (CAB14486)
The ETS2 Polyclonal Antibody (CAB14486) is specifically designed for research involving ETS2, a transcription factor that plays a critical role in cell growth, differentiation, and apoptosis. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the ETS2 protein, this antibody enables detection and analysis in various cell types, making it an essential tool for studies in cancer research and developmental biology.
ETS2 is known to regulate the expression of genes involved in cell proliferation and differentiation, making it a key player in tumor development and progression. Its significance in cancer biology makes it a valuable target for research focused on understanding the molecular mechanisms underlying tumorigenesis. By studying the activity of ETS2, researchers can gain insights into potential therapeutic targets for cancer treatment and develop novel strategies for combating cancer progression.
| Antibody Name: | Anti-ETS2 Antibody |
| Antibody SKU: | CAB14486 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 165-345 of human ETS2 (NP_005230.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 165-345 of human ETS2 (NP_005230.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QMIK ENQE KTED QYEE NSHL TSVP HWIN SNTL GFGT EQAP YGMQ TQNY PKGG LLDS MCPA STPS VLSS EQEF QMFP KSRL SSVS VTYC SVSQ DFPG SNLN LLTN NSGT PKDH DSPE NGAD SFES SDSL LQSW NSQS SLLD VQRV PSFE SFED DCSQ SLCL NKPT MSFK DYIQ ERSD PVEQ G |
| Gene ID: | 2114 |
| Uniprot: | P15036 |
| Cellular Location: | Nucleus |
| Calculated MW: | 53kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | ETS2, ETS2IT1 |
| Background: | This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Ets-2: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus E26 oncogene. A target of the Akt/JNK signaling pathway in macrophages. A PKC pathway activates ETS2, up-regulating GM-CSF in non-small lung carcinoma cells. |
| UniProt Protein Details: | Protein type:Transcription factor; Oncoprotein; DNA-binding Chromosomal Location of Human Ortholog: 21q22.2 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; DNA binding; transcription factor activity; glucocorticoid receptor binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; skeletal development |
| NCBI Summary: | This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P15036 |
| NCBI GenInfo Identifier: | 119645 |
| NCBI Gene ID: | 2114 |
| NCBI Accession: | P15036.1 |
| UniProt Secondary Accession: | P15036,A1A4L6, |
| UniProt Related Accession: | P15036 |
| Molecular Weight: | 469 |
| NCBI Full Name: | Protein C-ets-2 |
| NCBI Synonym Full Names: | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
| NCBI Official Symbol: | ETS2Â Â |
| NCBI Official Synonym Symbols: | ETS2IT1Â Â |
| NCBI Protein Information: | protein C-ets-2; oncogene ETS-2; v-ets erythroblastosis virus E26 oncogene homolog 2; v-ets avian erythroblastosis virus E2 oncogene homolog 2 |
| UniProt Protein Name: | Protein C-ets-2 |
| Protein Family: | Protein |
| UniProt Gene Name: | ETS2Â Â |
| UniProt Entry Name: | ETS2_HUMAN |
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