The ETFDH Polyclonal Antibody (PACO26561) is a valuable tool for researchers studying the ETFDH protein, which plays a crucial role in fatty acid metabolism. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ETFDH protein, this antibody allows for the detection and analysis of ETFDH in various cell types, making it an essential tool for studies in metabolic disorders and mitochondrial diseases.ETFDH is a key enzyme involved in electron transfer in the mitochondria, essential for the metabolism of fatty acids and amino acids.
Mutations in the ETFDH gene have been linked to various metabolic disorders, including multiple acyl-CoA dehydrogenase deficiency (MADD) and glutaric aciduria type II. Understanding the role of ETFDH in these diseases is crucial for developing targeted therapies and diagnostic tools.Overall, the ETFDH Polyclonal Antibody (PACO26561) provides researchers with a reliable and specific tool for investigating the role of ETFDH in metabolic disorders and mitochondrial diseases, advancing our understanding of these conditions and potential treatment options.
Antibody Name:
ETFDH Antibody (PACO26561)
Antibody SKU:
PACO26561
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Pig
Immunogen:
Recombinant Pig Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial protein (34-617AA)
Accepts electrons from ETF and reduces ubiquinone.
Synonyms:
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETF-QO) (ETF-ubiquinone oxidoreductase) (EC 1.5.5.1) (Electron-transferring-flavoprotein dehydrogenase) (ETF dehydrogenase), ETFDH
UniProt Protein Function:
ETFDH: Accepts electrons from ETF and reduces ubiquinone. Defects in ETFDH are the cause of glutaric aciduria type 2C (GA2C). GA2C is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Belongs to the ETF-QO/FixC family.Protein type: EC 1.5.5.1; Membrane protein, integral; Mitochondrial; Oxidoreductase
