The ESRRG Rabbit Monoclonal Antibody (CAB9606) is a high-quality antibody designed for research involving ESRRG, a member of the estrogen-related receptor (ERR) family of nuclear receptors. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for studies investigating the role of ESRRG in various cellular processes.ESRRG is known to play a critical role in regulating energy metabolism, mitochondrial function, and cell proliferation. It is also implicated in the development and progression of certain types of cancer, making it a promising target for cancer research.
The ESRRG Rabbit Monoclonal Antibody binds specifically to the ESRRG protein, allowing for accurate detection and analysis in a variety of cell types and experimental conditions.This antibody is validated for use in Western blot applications, providing researchers with a powerful tool for studying the function and mechanisms of ESRRG in immunology, cancer biology, and other fields. By understanding the role of ESRRG, researchers can gain valuable insights into the underlying mechanisms of disease and potentially identify new therapeutic targets for a range of conditions.
Product Name:
ESRRG Rabbit Monoclonal Antibody
SKU:
CAB9606
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ESRRG (P62508).
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
Purification Method:
Affinity purification
Gene ID:
2104
Clone Number:
ARC1653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ESRRG Rabbit mAb (CAB9606) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
