The ESR2 Polyclonal Antibody (CAB2546) is a valuable tool for researchers studying the estrogen receptor 2 (ESR2), a key player in hormone signaling pathways. This antibody, produced in rabbits, is highly specific to human ESR2 samples and is validated for Western blot applications. It binds to the ESR2 protein, allowing for precise detection and analysis in various cell types, making it an essential tool for studies in endocrinology, reproductive biology, and cancer research.ESR2, also known as estrogen receptor beta, is involved in regulating gene expression in response to estrogen and plays a crucial role in various physiological processes, including development, reproduction, and metabolism.
Dysregulation of ESR2 has been implicated in the pathogenesis of hormone-related cancers, such as breast and prostate cancer, as well as in conditions like osteoporosis and cardiovascular disease. Understanding the function and activity of ESR2 is essential for developing targeted therapies and personalized medicine approaches in these areas of research.
Product Name:
Estrogen Receptor beta Rabbit Polyclonal Antibody
SKU:
CAB2546
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-153 of human Estrogen Receptor beta (NP_001428.1).
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Purification Method:
Affinity purification
Gene ID:
2100
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Daudi cells using Estrogen Receptor beta Rabbit pAb(CAB2546) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
