ESR1 Monoclonal Antibody [LSERASC1] (CPAB0580)
- SKU:
- CPAB0580
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG
- Clone:
- LSERASC1
- Applications:
- WB
- IHC
- FC
Frequently bought together:
Description
system_update_alt Datasheet
Product Name: | ESR1 Antibody |
Product Sku: | CPAB0580 |
Size: | 500μg |
Host Species: | Mouse |
Immunogen: | Recombinant human ER-alpha. |
Clone: | LSERASC1. |
Reactivity: | Other bodies |
Applications: | Western Blot, Immunohistochemistry, Flow Cytometry |
Purification Method: | Protein A |
Isotype: | IgG |
Background: | Estrogen receptors ? (ER?, ER; NR3A1) is a member of the steroid hormone receptor family. ER? is a ligand-activated transcription factor. ER? contain DNA binding and ligand binding domains.  ER? is expressed in a wide variety of tissues, including ovary, uterus, breast, prostate, testis, epididymis, bones, bladder, kidney, heart, vessel wall, pituitary gland and hypothalamus. ER plays a variety of important roles in the maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.  The natural ligand for ER is 17?-estradiol, the classical estrogenic compound. The binding of estrogen to ER induces a conformational change and triggers a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. |
Synonyms: | ER-alpha |
Storage Buffer: | Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |