ESPL1 Rabbit Polyclonal Antibody (CAB15366)
- SKU:
- CAB15366
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | ESPL1 Rabbit Polyclonal Antibody |
SKU: | CAB15366 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1220-1500 of human ESPL1 (NP_036423.4). |
Sequence: | DEIL AQAY TLLA LEGL NQPS NESL QKVL QSGL KFVA ARIP HLEP WRAS LLLI WALT KLGG LSCC TTQL FASS WGWQ PPLI KSVP GSEP SKTQ GQKR SGRG RQKL ASAP LRLN NTSQ KGLE GRGL PCTP KPPD RIRQ AGPH VPFT VFEE VCPT ESKP EVPQ APRV QQRV QTRL KVNF SDDS DLED PVSA EAWL AEEP KRRG TASR GRGR ARKG LSLK TDAV VAPG SAPG NPGL NGRS RRAK KVAS RHCE ERRP QRAS DQAR PGPE IMRT IPEE ELTD NWRK M |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | ESP1; SEPA; ESPL1 |
Positive Sample: | HeLa,Jurkat,Mouse spleen,Rat spleen,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 233kDa |
Observed MW: | 233kDa |
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).
Purification Method: | Affinity purification |
Gene ID: | 9700 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |