The ERN2 Polyclonal Antibody (PACO03357) is a valuable tool for researchers studying ERN2, a key player in the unfolded protein response (UPR) pathway. This antibody, produced in rabbits, is highly specific for human ERN2 and has been validated for use in Western blot applications. By binding to the ERN2 protein, this antibody enables detection and analysis in various cell types, making it perfect for investigations in cell biology and disease mechanisms.ERN2, also known as endoplasmic reticulum to nucleus signaling 2, is essential for cellular stress responses and maintaining protein homeostasis.
Dysregulation of the UPR pathway, in which ERN2 plays a crucial role, has been linked to various diseases such as neurodegenerative disorders and metabolic syndromes. Therefore, studying ERN2 function with this antibody can provide insights into disease mechanisms and potential therapeutic targets for related conditions.
Antibody Name:
ERN2 Antibody
Antibody SKU:
PACO03357
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human IRE1alpha/Beta.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
IRE2: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Apoptosis; Protein kinase, Other; Membrane protein, integral; Ribonuclease; Other group; IRE familyChromosomal Location of Human Ortholog: 16p12.2Molecular Function: ATP binding; endonuclease activity; magnesium ion binding; protein serine/threonine kinase activityBiological Process: apoptotic chromosome condensation; negative regulation of transcription, DNA-dependent; protein amino acid phosphorylation; rRNA catabolic process
