IRE1 Rabbit Polyclonal Antibody (CAB17940)
- SKU:
- CAB17940
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | IRE1 Rabbit Polyclonal Antibody |
SKU: | CAB17940 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 286-435 of human IRE1 (NP_001424.3). |
Sequence: | VGKY STSL YASP SMVH EGVA VVPR GSTL PLLE GPQT DGVT IGDK GECV ITPS TDVK FDPG LKSK NKLN YLRN YWLL IGHH ETPL SAST KMLE RFPN NLPK HREN VIPA DSEK KSFE EVIN LVDQ TSEN APTT VSRD VEEK PAHA PARP EA |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | IRE1; IRE1P; IRE1a; hIRE1p |
Positive Sample: | 293T,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Single-pass type I membrane protein. |
Calculated MW: | 110kDa |
Observed MW: | 130kDa |
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Purification Method: | Affinity purification |
Gene ID: | 2081 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |