The Erlin1 Polyclonal Antibody (CAB14843) is a valuable tool for researchers studying Erlin1, a protein involved in lipid metabolism and endoplasmic reticulum (ER) function. This antibody is raised in rabbits and is highly reactive with samples from various species, including human, mouse, and rat. It has been validated for use in multiple applications, including Western blot, immunohistochemistry, and immunofluorescence.Erlin1 plays a crucial role in maintaining ER homeostasis and lipid metabolism, making it a key player in cellular functions such as protein folding and lipid synthesis. Dysfunction in Erlin1 has been linked to diseases like diabetes, neurodegenerative disorders, and cancer.
By using the Erlin1 Polyclonal Antibody, researchers can investigate the expression levels and localization of Erlin1 in different cell types and tissues, furthering our understanding of its role in health and disease.Overall, the Erlin1 Polyclonal Antibody is a reliable tool for studying Erlin1 biology and its implications in various physiological and pathological processes. Its versatility in different research applications makes it a valuable asset for scientists interested in unraveling the complexities of ER function and lipid metabolism.
Product Name:
ERLIN1 Rabbit Polyclonal Antibody
SKU:
CAB14843
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 259-348 of human ERLIN1 (NP_006450.2).
Endoplasmic reticulum membrane, Single-pass type II membrane protein.
Calculated MW:
39kDa
Observed MW:
39kDa
The protein encoded by this gene is part of a protein complex that mediates degradation of inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum. The encoded protein also binds cholesterol and regulates the SREBP signaling pathway, which promotes cellular cholesterol homeostasis. Defects in this gene have been associated with spastic paraplegia 62.
Purification Method:
Affinity purification
Gene ID:
10613
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERLIN1 Rabbit pAb (CAB14843) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
