The ERK5 Rabbit Monoclonal Antibody (CAB3948) is a cutting-edge tool for researchers investigating the ERK5 protein, a key player in various cellular processes including cell growth, differentiation, and survival. This antibody, generated from rabbit immunizations, exhibits high specificity and sensitivity towards human ERK5 protein, making it an ideal choice for Western blot applications.By targeting the ERK5 protein, this antibody allows for precise detection and analysis of ERK5 expression in different cell types, providing valuable insights into its function and regulation.
Its use is particularly valuable in studies related to cancer research, as dysregulation of the ERK5 signaling pathway has been implicated in tumor development and progression.Overall, the ERK5 Rabbit Monoclonal Antibody (CAB3948) serves as a powerful tool for researchers looking to delve into the intricate mechanisms of cellular signaling pathways and their implications in various diseases, paving the way for potential therapeutic interventions targeting the ERK5 pathway.
Product Name:
ERK5 Rabbit Monoclonal Antibody
SKU:
CAB3948
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 717-816 of human ERK5 (Q13164).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
5598
Clone Number:
ARC0871
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERK5 Rabbit mAb (CAB3948) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
