The ERI1 Antibody (PACO06026) is a polyclonal antibody designed for research involving ERI1, a crucial player in RNA metabolism and surveillance pathways. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the ERI1 protein, allowing for accurate detection and analysis in a variety of cell types, making it an essential tool for studies in RNA biology and disease pathology.ERI1 is known for its role in RNA degradation and quality control mechanisms, making it a key player in maintaining cellular homeostasis.
Dysregulation of ERI1 has been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and viral infections. Studying the function of ERI1 is crucial for understanding its impact on RNA stability and cellular processes, offering insights into potential therapeutic targets for a range of pathologies.Overall, the ERI1 Antibody (PACO06026) provides researchers with a reliable tool for investigating the function and expression of ERI1 in various cellular contexts, paving the way for advancements in RNA biology research and potential therapeutic interventions.
Antibody Name:
ERI1 Antibody (PACO06026)
Antibody SKU:
PACO06026
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human ERI1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
THEX1: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs. Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.Protein type: EC 3.1.-.-; Hydrolase; NucleolusChromosomal Location of Human Ortholog: 8p23.1Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: 3'-5' exonuclease activity; ribosome binding; rRNA bindingBiological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA 3'-end processing
