The ERG Polyclonal Antibody (CAB1240) is a valuable tool for researchers studying the ERG protein, a transcription factor involved in various biological processes, including cell proliferation and differentiation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot analysis.ERG is known for its role in modulating gene expression and has been implicated in the development of certain cancers, particularly prostate cancer. By targeting the ERG protein, researchers can gain insights into its function and potential as a therapeutic target for cancer treatment.
The ERG Polyclonal Antibody enables accurate and reliable detection of ERG protein levels in various cell types, providing researchers with the ability to investigate its impact on cell signaling pathways and disease progression. Its applications in cancer research and molecular biology make it an essential tool for understanding the biological mechanisms governed by the ERG transcription factor.
Product Name:
ERG Rabbit Polyclonal Antibody
SKU:
CAB1240
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ERG (NP_891548.1).
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
2078
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ERG antibody (CAB1240) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
