ERG Rabbit Polyclonal Antibody (CAB1240)
- SKU:
- CAB1240
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | ERG Rabbit Polyclonal Antibody |
SKU: | CAB1240 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ERG (NP_891548.1). |
Sequence: | MAST IKEA LSVV SEDQ SLFE CAYG TPHL AKTE MTAS SSSD YGQT SKMS PRVP QQDW LSQP PARV TIKM ECNP SQVN GSRN SPDE CSVA KGGK MVGS PDTV GMNY GSYM EEKH MPPP NMTT NERR VIVP ADPT LWST DHVR QWLE WAVK EYGL PDVN ILLF QNID GKEL CKMT KDDF QRLT PSYN ADIL LSHL HYLR ETPL PHLT SDDV DKAL QNSP RLMH ARNT GGAA FIFP NTSV YPEA TQRI TTRP DLPY EPPR RSAW TGHG HPTP QSKA AQPS PSTV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | p55; erg-3; ERG |
Positive Sample: | MCF7,THP-1,HeLa,BT-474,293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 54kDa |
Observed MW: | 60kDa |
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 2078 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |