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ERF Antibody (PACO03639)

SKU:
PACO03639
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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ERF Antibody (PACO03639)

The ERF Polyclonal Antibody (PACO03639) is an essential tool for researchers studying the ERF protein, a transcription factor involved in the regulation of gene expression. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in applications such as Western blotting. By binding to the ERF protein, this antibody enables researchers to detect and analyze ERF in various cell types, making it ideal for investigations in cell biology and cancer research.ERF, also known as Ets2 repressor factor, plays a crucial role in controlling gene expression in response to extracellular signals. Its involvement in cellular processes such as proliferation and differentiation makes it a key player in various diseases, including cancer and developmental disorders.

Understanding the function of ERF is essential for developing targeted therapies that aim to manipulate gene expression in these disease contexts.Overall, the ERF Polyclonal Antibody (PACO03639) is a valuable tool for researchers interested in studying the role of the ERF protein in gene regulation and disease progression. Its specificity and reliability make it a trusted resource for advancing our understanding of cellular processes and identifying potential therapeutic targets.

Antibody Name:ERF Antibody
Antibody SKU:PACO03639
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the C-terminal region of human ERF.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ERF; ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2
UniProt Protein Function:ERF: potent transcriptional repressor that binds to the H1 element of the ETS2 promoter. Belongs to the ETS family of transcription factors. Its function is regulated by phosphorylation.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: cytosol; Golgi apparatus; nucleoplasm; nucleus

Molecular Function:sequence-specific DNA binding; transcription corepressor activity

Biological Process: cell cycle; cell differentiation; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Craniosynostosis 4

NCBI Summary:ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
UniProt Code:P50548
NCBI GenInfo Identifier:50403684
NCBI Gene ID:2077
NCBI Accession:P50548.2
UniProt Secondary Accession:P50548,Q59G38, Q9UPI7, B2RAP1, B7Z4R0,
UniProt Related Accession:P50548
Molecular Weight:49,965 Da
NCBI Full Name:ETS domain-containing transcription factor ERF
NCBI Synonym Full Names:ETS2 repressor factor
NCBI Official Symbol:ERF  
NCBI Official Synonym Symbols:PE2; CRS4; PE-2  
NCBI Protein Information:ETS domain-containing transcription factor ERF
UniProt Protein Name:ETS domain-containing transcription factor ERF
UniProt Synonym Protein Names:Ets2 repressor factor; PE-2
Protein Family:Essential recombination function protein
UniProt Gene Name:ERF  
UniProt Entry Name:ERF_HUMAN

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